Sam's biggest challenge is that he is in a relationship with Addison but she is pulling away, so he ends up kissing Naomi which leads him to believe that maybe there is still a chance for a romantic relationship between them.
She is easing well into her new role as a grandmother, even though she was less than thrilled to find out her 16-year-old daughter Maya was pregnant.
Naomi eventually admits that she isn't happy with where her life is at the moment and makes a decision to find her purpose elsewhere.
He starts an affair with a writer who gave Violet's new book a bad review despite the warning from Cooper that the affair is going to jeopardise his friendship with Violet.
It is revealed that Amelia is a recovering substance abuser and that the reason she started in the first place was due to her father getting shot, which left her feeling empty and so she turned to drugs.
Charlotte gets Sheldon to help her with a patient is trying to get a sex change, but gets angry when Sheldon denies her patient the surgery.
Addison decides that she and Sam can't keep their relationship a secret, and tries to tell Naomi, but doesn't until the end of the day resulting in Naomi telling her to back her up with the merger.
She finally mends her relationship with her brother Derek Shepherd following his survival of a gunshot wound.
She is currently helping her friend deal with a fatal disease.
Addison and Sam continue their relationship, and eventually hit a rough patch when Addison decides that she wants a baby, and Sam doesn't want one because he already has Maya and Olivia.
Addison's life gets complicated when she is forced to sit by her mother's wife's side and watch her die, because of the DNR, and is faced with the repercussions when her mother commits suicide.
Sam and Addison are still dating but are at different points in their lives.